A Study of Cancer Antigen-125 as a Diagnostic Marker in Tuberculous and Malignant Pleural Effusion

Background: Cancer Antigen-125 (CA-125) was first identified as an ovary-specific tumor indicator but subsequently shown that inflammation exists even in the absence of polymorphism leads to this marker rise. Multiple locations tuberculosis (TB) produce increase serum antigen levels. This research objects estimate diagnostic value CA-125 and establish cut-off value, distinguishing tuberculous from malignant pleural effusion.
 Methods: prospective analytic case control study involved 90 subjects above 18 years old with a confirmed diagnosis effusion (TPE), (MPE) parapneumonic (PPE). Subjects were equally allocated into 3 groups: group I "Tuberculous": TPE, II "Malignant": MPE III "Control": PPE.
 Results: There positive significant correlation among fluid (group I) II).
 Conclusions: For reliable detection cause, might be included workup.